Solid gelatine capsules
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Technical characteristics
- Type of capsulesGelatin
- Type of releaseHard
Description
About us: Oral Solid Dosage Forms 453 More recently, the attention has moved to synthetic polymers with the aim being to pro-duce capsules that will overcome the shortcomings of gelatin, particularly its moisture con-tent. Two alternative materials have been offered by capsule manufacturers, starch andhydroxypropyl methylcellulose (HPMC). The starch capsules are produced by an injection moulding process using potato starch,and are produced in five sizes, all of the same diameter but with different lengths (Vilivalamet al. 2000). While the fill volumes are similar to gelatin capsules, the different dimensionsnecessitate specialised filling equipment. The capsule surface is less smooth than gelatin cap-sules, and the injection moulding allows a smooth join between cap and body to be obtained.These properties make the capsules amenable to film coating processes. The moisture contentof the capsules is 14 percent. HPMC capsules are made by the pin-dipping process used for gelatin capsules and aremade to the same size specifications, allowing them to be filled on conventional capsule fill-ing equipment. These capsules have a lower moisture content than gelatin capsules, and themoisture is tighter bound, making them more suitable for moisture sensitive drugs and hy-groscopic excipients. The capsule surfaces have rougher finishes than gelatin capsules, andcolouring the capsules is more difficult. The rough coat leads to better adhesion with coatingmaterials, so they could have applications for enteric coating.
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Solid gelatine capsules